非酒精性脂肪性肝炎
非酒精性脂肪肝
脂肪性肝炎
脂肪肝
脂肪变性
纤维化
疾病
慢性肝病
啮齿动物
肝病
医学
病理
病理生理学
生物
生物信息学
生理学
内科学
肝硬化
生态学
作者
Ghaidafeh Akbari,Seyyed Ali Mard,Feryal Savari,Barat Barati,Maryam Jafar Sameri
出处
期刊:PubMed
日期:2022-09-01
卷期号:37 (9): 813-824
被引量:1
摘要
Nonalcoholic fatty liver disease (NAFLD), as the most common chronic liver disease, is rapidly increasing worldwide. This complex disorder can include simple liver steatosis to more serious stages of nonalcoholic fibrosis and steatohepatitis (NASH). One of the critical concerns in NASH research is selecting and confiding in relying on preclinical animal models and experimental methods that can accurately reflect the situation in human NASH. Recently, creating nutritional models of NASH with a closer dietary pattern in human has been providing reliable, simple, and reproducible tools that hope to create a better landscape for showing the recapitulation of disease pathophysiology. This review focuses on recent research on rodent models (mice, rats, and hamsters) in the induction of the dietary model of NAFLD /NASH. This research tries to compile the different dietary compositions of NASH, time frames required for disease development, and their impact on liver histological features as well as metabolic parameters.
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