Impact of Graves Disease on Ocular Surface and Corneal Epithelial Thickness in Patients With and Without Graves Orbitopathy

医学 眼科 希默试验 Graves眼病 眼泪 角膜 疾病 眼病 干眼症 内科学 格雷夫斯病 外科
作者
Ana Rita Carreira,Sandra Rodrigues-Barros,Filipe Moraes,Tomás Loureiro,Inês Machado,Paul Campos,João Cardoso,Nuno Campos
出处
期刊:Cornea [Ovid Technologies (Wolters Kluwer)]
卷期号:41 (4): 443-449 被引量:8
标识
DOI:10.1097/ico.0000000000002753
摘要

Our aim was to assess ocular surface and tear film stability and corneal epithelial thickness (CET) in patients with Graves disease (GD) with and without Graves orbitopathy (GO).This study included healthy age-matched controls and patients with GD. Symptoms (Ocular Surface Disease Index questionnaire) and signs (schirmer test and tear breakup time test) of dry eye disease were determined, according to the International Dry Eye Workshop II criteria of DED. CET map was also assessed.Twenty-four eyes were included in the control group, with a mean age of 41.00 ± 13.65 years, and 34 in the GD group, 18 with GO and 16 without GO, with a mean age of 44.44 ± 13.95 and 45.75 ± 10.59 years, respectively. All patients with GO had inactive disease (mean clinical activity score: 1.33 ± 0.69). Patients with GD had higher proportion of clinical diagnosis of dry eye disease (GO vs. GD without GO vs. controls: 77.77% vs. 75.00% vs. 4.17%), with higher Ocular Surface Disease Index (GO vs. GD without GO vs. controls: 15.44 vs. 15.06 vs. 9.88) and lower tear breakup time test (GO vs. GD without GO vs. controls: 6.33 s vs. 7.25 s vs. 11.63 s). Superior CET was lower in patients with GD (P < 0.05). No differences were found between patients with and without GO (P > 0.05).GD negatively influenced ocular surface and CET, with a higher level of eye dryness and corneal thinning regardless of GO status, suggesting that subclinical chronic inflammation may play a role in the pathogenesis of tear film and ocular surface stability.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
lfg完成签到,获得积分10
1秒前
活泼的便当完成签到,获得积分10
1秒前
流浪完成签到,获得积分10
1秒前
2秒前
2秒前
lili发布了新的文献求助10
3秒前
luchong完成签到,获得积分10
3秒前
LDDD发布了新的文献求助10
4秒前
onethree完成签到 ,获得积分10
5秒前
完美世界应助LZY采纳,获得10
5秒前
雪白起眸发布了新的文献求助10
5秒前
5秒前
扶手发布了新的文献求助10
5秒前
5秒前
genomed应助pray采纳,获得10
5秒前
江河发布了新的文献求助10
6秒前
不配.应助joyboy采纳,获得10
6秒前
gl发布了新的文献求助10
6秒前
6秒前
6秒前
梨子完成签到,获得积分10
8秒前
李昆朋完成签到,获得积分10
8秒前
lili完成签到,获得积分10
8秒前
9秒前
梅子酒发布了新的文献求助10
9秒前
9秒前
LDDD完成签到,获得积分10
9秒前
luchong发布了新的文献求助30
10秒前
科研绿老头完成签到 ,获得积分10
10秒前
11秒前
十里八乡俊后生完成签到,获得积分10
11秒前
小柴乖乖发布了新的文献求助10
13秒前
上官若男应助Heavenfalling采纳,获得10
13秒前
14秒前
大个应助科研通管家采纳,获得10
14秒前
大个应助科研通管家采纳,获得10
14秒前
在望应助科研通管家采纳,获得10
14秒前
英姑应助科研通管家采纳,获得200
14秒前
李爱国应助科研通管家采纳,获得10
14秒前
高分求助中
Write Like a Chemist: A Guide and Resource (第二版) 600
Mixed-anion Compounds 600
A new species of Velataspis (Hemiptera Coccoidea Diaspididae) from tea in Assam 500
Earth System Geophysics 500
Aspects of Babylonian celestial divination: the lunar eclipse tablets of Enūma Anu Enlil 500
Geochemistry, 2nd Edition 地球化学经典教科书第二版 401
2024 Medicinal Chemistry Reviews 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3201273
求助须知:如何正确求助?哪些是违规求助? 2850854
关于积分的说明 8074942
捐赠科研通 2514733
什么是DOI,文献DOI怎么找? 1347411
科研通“疑难数据库(出版商)”最低求助积分说明 640427
邀请新用户注册赠送积分活动 610621