Impact of Graves Disease on Ocular Surface and Corneal Epithelial Thickness in Patients With and Without Graves Orbitopathy

医学 眼科 希默试验 Graves眼病 眼泪 角膜 疾病 眼病 干眼症 内科学 格雷夫斯病 外科
作者
Ana Rita Carreira,Sandra Rodrigues-Barros,Filipe Moraes,Tomás Loureiro,Inês Machado,Paul Campos,João Cardoso,Nuno Campos
出处
期刊:Cornea [Ovid Technologies (Wolters Kluwer)]
卷期号:41 (4): 443-449 被引量:8
标识
DOI:10.1097/ico.0000000000002753
摘要

Our aim was to assess ocular surface and tear film stability and corneal epithelial thickness (CET) in patients with Graves disease (GD) with and without Graves orbitopathy (GO).This study included healthy age-matched controls and patients with GD. Symptoms (Ocular Surface Disease Index questionnaire) and signs (schirmer test and tear breakup time test) of dry eye disease were determined, according to the International Dry Eye Workshop II criteria of DED. CET map was also assessed.Twenty-four eyes were included in the control group, with a mean age of 41.00 ± 13.65 years, and 34 in the GD group, 18 with GO and 16 without GO, with a mean age of 44.44 ± 13.95 and 45.75 ± 10.59 years, respectively. All patients with GO had inactive disease (mean clinical activity score: 1.33 ± 0.69). Patients with GD had higher proportion of clinical diagnosis of dry eye disease (GO vs. GD without GO vs. controls: 77.77% vs. 75.00% vs. 4.17%), with higher Ocular Surface Disease Index (GO vs. GD without GO vs. controls: 15.44 vs. 15.06 vs. 9.88) and lower tear breakup time test (GO vs. GD without GO vs. controls: 6.33 s vs. 7.25 s vs. 11.63 s). Superior CET was lower in patients with GD (P < 0.05). No differences were found between patients with and without GO (P > 0.05).GD negatively influenced ocular surface and CET, with a higher level of eye dryness and corneal thinning regardless of GO status, suggesting that subclinical chronic inflammation may play a role in the pathogenesis of tear film and ocular surface stability.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
lxrong完成签到,获得积分10
1秒前
1秒前
2秒前
linyican完成签到,获得积分10
3秒前
加菲丰丰应助霸气以菱采纳,获得20
4秒前
7秒前
十一完成签到 ,获得积分10
7秒前
7秒前
李健的粉丝团团长应助lyn采纳,获得10
9秒前
不配.应助雪白的雪采纳,获得30
9秒前
9秒前
鲜艳的远航完成签到,获得积分10
10秒前
10秒前
10秒前
小二郎应助艾斯喜爱采纳,获得10
10秒前
合适的铃铛完成签到,获得积分10
11秒前
14秒前
14秒前
蚂蚁牙黑完成签到,获得积分10
14秒前
云风发布了新的文献求助10
15秒前
阡陌完成签到 ,获得积分10
15秒前
15秒前
15秒前
在水一方应助fifteen采纳,获得10
16秒前
18秒前
深情安青应助ZY1999采纳,获得10
20秒前
传奇3应助哈哈哈哈采纳,获得10
20秒前
Alnair发布了新的文献求助10
21秒前
21秒前
ke发布了新的文献求助10
22秒前
22秒前
22秒前
椰子冰完成签到,获得积分10
23秒前
艾斯喜爱发布了新的文献求助10
25秒前
FashionBoy应助makimaki采纳,获得10
26秒前
duolaAmeng完成签到,获得积分10
26秒前
caotq发布了新的文献求助10
28秒前
29秒前
31秒前
xiaodaiduyan发布了新的文献求助10
32秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
ALA生合成不全マウスでの糖代謝異常の分子機構解析 520
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
2-Acetyl-1-pyrroline: an important aroma component of cooked rice 500
A real-time energy management strategy based on fuzzy control and ECMS for PHEVs 400
Handbook on People's China (1957) 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3189376
求助须知:如何正确求助?哪些是违规求助? 2838682
关于积分的说明 8021170
捐赠科研通 2501595
什么是DOI,文献DOI怎么找? 1335815
科研通“疑难数据库(出版商)”最低求助积分说明 637711
邀请新用户注册赠送积分活动 605784