转录激活物样效应核酸酶
基因组编辑
清脆的
锌指核酸酶
RNA干扰
计算生物学
生物
小发夹RNA
效应器
遗传增强
小干扰RNA
基因组工程
Cas9
基因敲除
基因
遗传学
核糖核酸
细胞生物学
作者
Xiaomei Zhang,Xin Jin,Rui Sun,Meng Zhang,Wenyi Lu,Mingfeng Zhao
出处
期刊:Cancer Letters
[Elsevier]
日期:2022-08-01
卷期号:540: 215736-215736
被引量:9
标识
DOI:10.1016/j.canlet.2022.215736
摘要
Cellular immunotherapy has achieved incremental success in recent years. Varieties of cell products are undergoing fundamental research and clinical trials, among which CAR-T cell therapy is approved for marketing. As research progresses, these cells need to be modified to promote their safety and efficacy. Gene-editing technologies have evolved from RNA interference (RNAi), including small interfering RNAs (siRNAs) and short hairpin RNAs (shRNAs), to new generations of zinc finger nucleases (ZFNs), transcription-activator-like effector nucleases (TALENs), and clusters of regularly spaced short palindromic repeats (CRISPR/Cas9), and delivery methods are widely used. Here, we summarize the ongoing clinical trials and fundamental research for genome editing therapy. Additionally, we highlight existing in vivo delivery systems and their limitations to find a better method to deliver genes.
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