化学
芳基
苯甲酸
卤化
复分解
碘化物
试剂
药物化学
有机化学
组合化学
烷基
聚合
聚合物
作者
Zezhong Gao,Hang Wang,Chunlin Zhou,Ning Wang,Shangda Li,Gang Li
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-05-31
卷期号:24 (22): 3926-3931
被引量:8
标识
DOI:10.1021/acs.orglett.2c01224
摘要
C-H functionalization via functional group metathesis is extremely rare. A protocol of remote site-selective C-H iodination of 2-aryl benzoic acid derivatives via formal C(sp2)-H/C(sp2)-I metathesis using readily available 1-iodo-4-methoxy-2-nitrobenzene as the mild iodinating reagent was reported herein. A range of 2-aryl benzoic acid derivatives including 2-(naphthalen-1-yl)benzoic acids and [1,1'-binaphthalene]-2-carboxylic acids were iodinated under mild conditions to give valuable iodinated products in a site- and chemo-selective fashion.
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