Inhibitory effects of a smartphone‐controlled wearable transcutaneous tibial nerve stimulation device on bladder reflexes in anesthetized cats

Abstract Objectives To explore the inhibitory effects of a novel, smartphone‐controlled, and wearable tibial nerve stimulation device on nonnociceptive and nociceptive bladder reflexes in anesthetized cats and to compare the stimulus results of two current waveforms outputted by this new stimulator. Materials and Methods A novel, intelligent tibial nerve stimulator was put on the ankles of 14 cats and controlled by a mobile application. Cystometrograms (CMGs) were performed repeatedly by infusing 0.9% normal saline (NS) and 0.5% acetic acid (AA) through a urethral catheter. Inhibitory effects were explored by measuring the bladder capacity (BC) in two areas: (1) on nonnociceptive bladder reflex (infused with NS) and on nociceptive bladder reflex (filled with AA to induce overactive bladder [OAB] model); and (2) under the stimulation of two different current waveforms (waveforms A and B). Results In Group 1, the BC of AA‐induced OAB (41.48 ± 8.40%) was significantly different compared with the capacity of a NS‐infused bladder (104.89 ± 1.32%, p < 0.05). Both NS‐filled (151.35 ± 5.71%, p < 0.05) and AA‐instilled (71.41 ± 9.34%, p < 0.05) bladder volumes significantly increased after tibial nerve stimulation (TNS). In Group 2, the BC increased to 166.18 ± 15.17% ( p = 0.026) and 127.64 ± 13.00% ( p = 0.239), respectively, after TNS with waveforms A and B current. Conclusions Results revealed that this novel, smartphone‐based, wearable, and wireless tibial nerve stimulation system could inhibit the micturition reflex on physiological condition, serving as a potential option for OAB treatment. In addition, the waveforms of stimulation current had an important influence on the effects of TNS.