A Comprehensive Review on the Electrochemical Sensing of Flavonoids.

Flavonoids are bioactive polyphenolic compounds, widespread in the plant kingdom. Flavonoids possess broad-spectrum pharmacological effects due to their antioxidant, anti-tumor, anti-neoplastic, anti-mutagenic, anti-microbial, anti-inflammatory, anti-allergic, immunomodulatory, and vasodilatory properties. Care must be taken, since excessive consumption of flavonoids may have adverse effects. Therefore, proper identification, quantification and quality evaluations of flavonoids in edible samples are necessary. Electroanalytical approaches have gained much interest for the analysis of redox behavior and quantification of different flavonoids. Compared to various conventional methods, electrochemical techniques for the analysis of flavonoids offer advantages of high sensitivity, selectivity, low cost, simplicity, biocompatibility, easy on-site evaluation, high accuracy, reproducibility, wide linearity of detection, and low detection limits. This review article focuses on the developments in electrochemical sensing of different flavonoids with emphasis on electrode modification strategies to boost the electrocatalytic activity and analytical efficiency.