已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Gait‐Related Metabolic Covariance Networks at Rest in Parkinson's Disease

步态 脑岛 帕金森病 物理医学与康复 神经科学 神经影像学 辅助电机区 心理学 背外侧前额叶皮质 楔前 前额叶皮质 医学 内科学 疾病 认知 功能磁共振成像
作者
Hilmar P. Sigurdsson,Alison J. Yarnall,Brook Galna,Sue Lord,Lisa Alcock,Rachael A. Lawson,Sean J. Colloby,Michael Firbank,John‐Paul Taylor,Nicola Pavese,David J. Brooks,John T. OʼBrien,David J. Burn,Lynn Rochester
出处
期刊:Movement Disorders [Wiley]
卷期号:37 (6): 1222-1234 被引量:11
标识
DOI:10.1002/mds.28977
摘要

Gait impairments are characteristic motor manifestations and significant predictors of poor quality of life in Parkinson's disease (PD). Neuroimaging biomarkers for gait impairments in PD could facilitate effective interventions to improve these symptoms and are highly warranted.The aim of this study was to identify neural networks of discrete gait impairments in PD.Fifty-five participants with early-stage PD and 20 age-matched healthy volunteers underwent quantitative gait assessment deriving 12 discrete spatiotemporal gait characteristics and [18 F]-2-fluoro-2-deoxyglucose-positron emission tomography measuring resting cerebral glucose metabolism. A multivariate spatial covariance approach was used to identify metabolic brain networks that were related to discrete gait characteristics in PD.In PD, we identified two metabolic gait-related covariance networks. The first correlated with mean step velocity and mean step length (pace gait network), which involved relatively increased and decreased metabolism in frontal cortices, including the dorsolateral prefrontal and orbital frontal, insula, supplementary motor area, ventrolateral thalamus, cerebellum, and cuneus. The second correlated with swing time variability and step time variability (temporal variability gait network), which included relatively increased and decreased metabolism in sensorimotor, superior parietal cortex, basal ganglia, insula, hippocampus, red nucleus, and mediodorsal thalamus. Expression of both networks was significantly elevated in participants with PD relative to healthy volunteers and were not related to levodopa dosage or motor severity.We have identified two novel gait-related brain networks of altered glucose metabolism at rest. These gait networks could serve as a potential neuroimaging biomarker of gait impairments in PD and facilitate development of therapeutic strategies for these disabling symptoms. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
2秒前
科研通AI2S应助GL采纳,获得10
2秒前
chujun_cai完成签到 ,获得积分10
2秒前
5秒前
7秒前
刺猬发布了新的文献求助10
7秒前
jiaaniu完成签到 ,获得积分10
10秒前
阿九发布了新的文献求助10
10秒前
11秒前
14秒前
16秒前
小二郎应助刺猬采纳,获得10
16秒前
小西米完成签到 ,获得积分10
17秒前
wanglejia完成签到,获得积分10
18秒前
21秒前
GL发布了新的文献求助10
21秒前
xiemeili完成签到 ,获得积分10
22秒前
无聊又夏完成签到,获得积分10
22秒前
23秒前
muyangsiyuan完成签到,获得积分10
30秒前
轻松的惜芹应助CC采纳,获得10
31秒前
33秒前
35秒前
yuntong完成签到 ,获得积分0
35秒前
35秒前
迷路的依波完成签到,获得积分10
36秒前
简单山水发布了新的文献求助10
38秒前
38秒前
40秒前
Milesgao发布了新的文献求助10
42秒前
44秒前
李爱国应助科研通管家采纳,获得10
44秒前
ding应助科研通管家采纳,获得100
45秒前
隐形曼青应助科研通管家采纳,获得10
45秒前
czh应助科研通管家采纳,获得10
45秒前
迷你的夏菡完成签到 ,获得积分10
46秒前
Beyond095完成签到 ,获得积分10
54秒前
从容成危完成签到,获得积分10
56秒前
yang完成签到 ,获得积分10
58秒前
聆琳完成签到 ,获得积分10
58秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
Aktuelle Entwicklungen in der linguistischen Forschung 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989972
求助须知:如何正确求助?哪些是违规求助? 3532034
关于积分的说明 11256042
捐赠科研通 3270884
什么是DOI,文献DOI怎么找? 1805093
邀请新用户注册赠送积分活动 882256
科研通“疑难数据库(出版商)”最低求助积分说明 809216