荟萃分析
冲程(发动机)
康复
迷走神经电刺激
医学
置信区间
随机对照试验
不利影响
物理疗法
物理医学与康复
中风恢复
迷走神经
内科学
刺激
机械工程
工程类
作者
Yilin Liu,Liping Zhang,Xin Zhang,Jue Ma,Gongwei Jia
标识
DOI:10.1016/j.jstrokecerebrovasdis.2022.106390
摘要
To evaluate the effectiveness of vagus nerve stimulation (VNS) combined with rehabilitation therapies in restoring upper extremity (UE) function following stroke. Data Sources A search was implemented in key databases along with hand searches of relevant papers and performed on 31 July 2021.Only randomized controlled trials (RCTs) assessing the effect of VNS focusing on UE dysfunction in patients post-stroke were identified in this systematic review. Data were extracted independently by two authors. The study was conducted by the Preferred Reporting Items for Meta-Analyses (PRISMA) guidelines. Meta-analyses were performed when deemed feasible.Five RCTs involving 178 patients (VNS/C 87/91) were included. The primary outcome was the function assessment by upper UE Fugl-Meyer assessment (FMA-U). As secondary outcomes, strength was assessed with the Wolf motor function test (WMFT), the Stroke Impact Scale (SIS) and the Motor Activity Log (MAL). Meta-analysis showed a significant immediate favoring VNS-based rehabilitation (five studies) for improving upper extremity function after stroke (mean difference [MD] 3.31; 95% confidence interval [CI], 2.33-4.29; p < 0.0001,fixed-effects model), along the lines of the long-term effect (three studies) (MD = 3.13; 95% CI, 1.47--4.79; p < 0.0001,fixed-effects model). No effect was observed when compared with control groups in adverse outcomes (Risk Ratio [RR] 1.61; 95% CI, 0.65-3.99; P = 0.30).VNS combined with rehabilitation training may be considered as a promising intervention in UE recovery in stroke patients.
科研通智能强力驱动
Strongly Powered by AbleSci AI