Detecting the combined toxicity of 18 binary and 24 ternary pesticide combinations to carboxylesterase based on fluorescence probe technology

多菌灵 化学 益达胺 杀虫剂 毒死蜱 毒性 毒理 色谱法 氨基甲酸酯 环境化学 杀菌剂 生物化学 有机化学 生物 植物 农学
作者
Xinyue Zhu,Lisen Chen,Tao Liu,Shengui He,Xin Zhao,Yinong Tian,Yanjun Fang,Jingnan Cui
出处
期刊:Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes [Taylor & Francis]
卷期号:57 (4): 305-315 被引量:4
标识
DOI:10.1080/03601234.2022.2049158
摘要

A rapid test method for the determination of pesticide toxicity was established by using carboxylesterase (CES) and fluorescence probe ACE-NH based on the principle of enzyme inhibition, and this method was applied to detect the combined toxicity of 18 binary and 24 ternary pesticide combinations commonly used for fruits and vegetables to CES. The results show that chlorpyrifos + carbendazim, carbofuran + carbendazim, imidacloprid + carbendazim, imidacloprid + dimethomorph, dimethoate + dimethomorph, prochloraz + carbendazim and imidacloprid + acetamiprid + carbendazim had synergistic effects under three concentration gradients, it indicated that most binary combinations containing carbendazim or imidacloprid had synergistic effects. Based on structure-activity relationship between pesticides and CES, pesticides with phosphate ester bonds had great toxicity to CES, or though they have no toxicity to CES alone, they showed a strong synergistic effect when mixed with other pesticides. Pesticides with amide or ester bond had medium toxicity and little synergistic effect. Pesticides with urea, carbamate or nitrite nitrogen group had little or no toxicity, while there was a strong synergistic effect after mixing with other pesticides. The test method and results in this study can provide scientific basis for risk assessment of cumulative exposure to mixed pesticide residues.
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