光动力疗法
伊诺斯
肿瘤微环境
癌症研究
一氧化氮
单线态氧
癌症治疗
化学
细胞生物学
肿瘤细胞
医学
药理学
一氧化氮合酶
癌症
生物
氧气
内科学
有机化学
作者
Shuaiqiang Zhang,Yuanhao Li,Zhuoyue Li,Guangxue Wang,Ai-Ho Liao,Jingru Wang,Hui Li,Zefeng Guo,Boyang Cheng,Xuan Zhang
出处
期刊:Small
[Wiley]
日期:2022-03-25
卷期号:18 (17)
被引量:17
标识
DOI:10.1002/smll.202200038
摘要
Abstract Tumor microenvironment (TME)‐responsive intelligent photodynamic therapy (PDT) systems have attracted increasing interest in anticancer therapy, due to their potential to address significant and unsatisfactory therapeutic issues, such as limited tissue penetration, inevitable normal tissue damage, and excessive impaired vessels. Here, an H 2 O 2 ‐triggered intelligent LCL/ZnO PDT nanodelivery system is elaborately designed. LCL/ZnO can selectively regulate tumor‐derived endothelial cells (TECs) and specifically kill tumor cells, by responding to different H 2 O 2 gradients in TECs and tumor cells. The LCL/ZnO is able to normalize tumor vessels, thereby resulting in decreased metastases, and ameliorating the immunosuppressive TME. Further analysis demonstrates that singlet oxygen ( 1 O 2 )‐activated transient receptor potential vanilloid‐4‐endothelial nitric oxide synthase signals generated in TECs by LCL/ZnO induce tumor vascular normalization, which is identified as a novel mechanism contributing to the increased ability of PDT to promote cancer therapy. In conclusion, designing an intelligent PDT nanodelivery system response to the TME, that includes both selective TECs regulation and specific tumor‐killing, will facilitate the development of effective interventions for future clinical applications.
科研通智能强力驱动
Strongly Powered by AbleSci AI