Tröger's Base Derivatives—New Life for Old Compounds

Synthetic Tröger's base derivatives are reviewed, including their properties and applications. The rigid V-shaped Tröger's base framework and its inherent chirality have promoted the preparation of diverse receptor systems. Heterocyclic Tröger's base derivatives exhibit affinity for DNA. Metal complexes of Tröger's base are used as catalysts. New applications continue to emerge as synthetic methods are developed.