Elevated Platelet-Derived Growth Factor AB/BB is Associated with a Lower Risk of Recurrent Vascular Events in Stroke Patients

医学 冲程(发动机) 内科学 风险因素 心脏病学 缺血性中风 缺血 机械工程 工程类
作者
Kaavya Narasimhalu,Lal Krishna U,Deidre Anne De Silva,Meng‐Cheong Wong,Hui‐Meng Chang,Christopher Chen
出处
期刊:International Journal of Stroke [SAGE Publishing]
卷期号:10 (1): 85-89 被引量:11
标识
DOI:10.1111/ijs.12358
摘要

Background Platelet-derived growth factor (PDGF)-AB and BB have been shown to possess angiogenic properties in vivo, and decreased levels have been linked to plaque instability in atherosclerosis. Little work has been done to determine if PDGF is associated with outcomes after stroke, in particular cognitive outcomes. Therefore, in this sudy, we investigated the association between PDGFand both vascular and cognitive outcomes in a cohort of patients with recent nondisabling ischemic stroke. Methods Three hundred nine patients recruited within six-months of a transient ischemic attack or nondisabling ischemic stroke [modified Rankin Scale (mRS) ⩽ 3] were followed for up to five-years. Cox proportional-hazard regression analyses were performed to investigate the association of PDGF levels with the risk of death, recurrent vascular events, dependency, and incident dementia, while logistic regression analyses were performed to investigate the association of PDGF levels with the risk of significant cognitive decline. Significant cognitive decline was defined as: (a) a decline of cognitive status from no cognitive impairment or mild cognitive impairment with no dementia to moderate cognitive impairment with no dementia or (b) conversion to dementia. Results Patients (mean age 60 years) were mostly male (64%) and of Chinese ethnicity (85%) and had posterior circulation or lacunar infarcts (73%). In univariate analysis, PDGF was significantly associated with a lower risk of recurrent vascular events [hazard ratio (HR) 0·61; 95% confidence interval (CI) 0·44–0·84]. In multivariate analysis adjusting for treatment, PDGF was independently associated with a lower risk of recurrent vascular events (HR 0·62; 95% CI 0·46–0·85). PDGF levels were not associated with the risk of the other outcomes of interest. Conclusions Higher levels of PDGF-AB/BB were independently associated with a lower risk of recurrent vascular events in a cohort of convalescent nondisabled stroke patients. Our findings suggest that PDGF-AB/BB may potentially serve as a prognostic marker for outcomes pos- stroke and, if this result is validated in larger samples, a potential therapeutic target.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
大橙子发布了新的文献求助10
4秒前
张牧之完成签到 ,获得积分10
6秒前
冷冷暴力完成签到,获得积分10
8秒前
YYY完成签到,获得积分10
8秒前
8秒前
gujian完成签到 ,获得积分10
11秒前
帅气的秘密完成签到 ,获得积分10
12秒前
自然函发布了新的文献求助10
16秒前
冰冰双双完成签到,获得积分10
16秒前
开心夏旋完成签到 ,获得积分0
18秒前
我要读博士完成签到 ,获得积分10
21秒前
活泼的大船完成签到,获得积分10
21秒前
AFF完成签到,获得积分10
22秒前
23秒前
无私小小完成签到,获得积分10
24秒前
随心所欲完成签到 ,获得积分10
25秒前
润润轩轩完成签到 ,获得积分10
26秒前
CodeCraft应助大橙子采纳,获得10
26秒前
ZR完成签到,获得积分10
27秒前
magictoo完成签到,获得积分10
27秒前
陈昊发布了新的文献求助10
28秒前
zhangliangfu完成签到 ,获得积分10
28秒前
金石为开完成签到,获得积分10
28秒前
王QQ完成签到 ,获得积分10
30秒前
唐唐完成签到 ,获得积分10
34秒前
最棒哒完成签到 ,获得积分10
34秒前
鸣鸣完成签到,获得积分10
35秒前
123321完成签到 ,获得积分10
36秒前
卓若之完成签到 ,获得积分10
37秒前
苯二氮卓完成签到,获得积分10
38秒前
温暖完成签到 ,获得积分10
40秒前
mojomars完成签到,获得积分10
40秒前
时尚雨兰完成签到,获得积分0
41秒前
一叶知秋完成签到,获得积分10
43秒前
叶123完成签到,获得积分10
44秒前
量子星尘发布了新的文献求助10
45秒前
Minicoper发布了新的文献求助10
45秒前
背书强完成签到 ,获得积分10
46秒前
淡然以柳完成签到 ,获得积分10
48秒前
dolabmu完成签到 ,获得积分10
51秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038128
求助须知:如何正确求助?哪些是违规求助? 3575831
关于积分的说明 11373827
捐赠科研通 3305610
什么是DOI,文献DOI怎么找? 1819255
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022