医学
凝血酶原时间
部分凝血活酶时间
胃肠病学
养生
新鲜冰冻血浆
肝活检
凝结
内科学
凝血酶原复合物浓缩物
混凝试验
慢性肝炎
凝血活酶
肝病
体重
外科
活检
免疫学
华法林
血小板
病毒
心房颤动
作者
Pier Mannuccio Mannucci,Franca Franchi,N Dioguardi
出处
期刊:The Lancet
[Elsevier]
日期:1976-09-01
卷期号:308 (7985): 542-545
被引量:87
标识
DOI:10.1016/s0140-6736(76)91794-3
摘要
Abstract
The effect on abnormal coagulation tests of infusions of fresh-frozen plasma (F.F.P.), prothrombin complex concentrates, and a combination of these treatments was compared in 30 patients with chronic liver disease undergoing needle biopsy. A single dose of F.F.P. (12 ml/kg body-weight) was found to be the least effective therapeutic regimen The concentrate containing factors II, IX, and x was also not adequate, but the additional administration of factor-VII concentrate corrected the prothrombin-time (P.T.) and 'Normotest' (N.T.) in most patients. However, this regimen did not correct the prolonged kaolin activated partial thromboplastin-time (K.P.T.T.). The results of tests for exploring both the extrinsic (P.T. and N.T.) and intrinsic (K.P.T.T.) coagulation systems only became normal after the combined administration of a lower dose of F.F.P. (8 ml/kg body-weight) and of both concen trates (12 units/ml). There was no clinical or laboratory evidence of thrombotic complications. No patient developed acute hepatitis or hepatitis-B surface antigen in the twelve months after biopsy. These results indicate that prothrombin-complex concentrates in combination with F.F.P. may therefore be used to allow liver biopsy to be performed safely in patients presenting with severe coagulation defects.
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