Atypical fractures and bisphosphonate therapy: A cohort study of patients with femoral fracture with radiographic adjudication of fracture site and features

医学 双膦酸盐 射线照相术 队列 外科 低能 骨质疏松症 内科学 物理 原子物理学
作者
Andrea Giusti,Neveen A. T. Hamdy,Olaf M. Dekkers,Sharita R Ramautar,P.D.S. Dijkstra,Socrates E. Papapoulos
出处
期刊:Bone [Elsevier BV]
卷期号:48 (5): 966-971 被引量:183
标识
DOI:10.1016/j.bone.2010.12.033
摘要

Atypical subtrochanteric/femoral shaft (ST/FS) fractures are increasingly reported in patients on long-term treatment with bisphosphonates (BPs). We estimated the frequency of atypical fractures and their association to BP use in patients aged ≥ 50 years consecutively admitted to a single center with a new femoral fracture. All individual radiographs were examined and fracture site confirmed. A case-control study of patients with low-energy ST/FS fractures, age- and sex-matched with patients with hip fractures (1:2 ratio), was performed. Patients with atypical ST/FS fractures were further compared with those with ordinary ST/FS fractures. Cortical thickness (CT) was measured in radiographs of cases and controls. Ninety-six of 906 patients (10.6%) had a ST/FS fracture. Of these, 63 with low-energy fractures were individually matched with 126 controls with hip fracture. BPs were used by 9.5% of cases and by 8.7% of controls (OR, 1.10; 95% CI, 0.39-3.06) with comparable duration of therapy between groups (54 ± 35 vs. 54 ± 52 months, P=0.53). CT was comparable between cases and controls, BP users and non-users, and was not related to treatment duration. Atypical fractures were observed in 10/63 ST/FS cases (15.9%). Compared to patients with ordinary ST/FS fractures, those with atypical fractures were using more frequently BPs (OR, 17.0; 95% CI, 2.6-113.3) and glucocorticoids (OR, 5.3; 95% CI, 0.9-28.6). Among patients with atypical fractures, CT was comparable between BP users and non-users. In conclusion, atypical femoral fractures have a low prevalence (1.1% of all femoral fractures), compared to ordinary ST/FS fractures are more frequent in bisphosphonate users, but equally occur in patients never treated with bisphosphonates.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Jasper应助lishuai采纳,获得10
1秒前
HH完成签到 ,获得积分10
1秒前
寒冷归尘完成签到,获得积分20
2秒前
Owen应助HY采纳,获得10
2秒前
3秒前
复杂听筠发布了新的文献求助30
3秒前
爆米花应助椰子采纳,获得10
3秒前
4秒前
银匠完成签到,获得积分10
4秒前
tyy发布了新的文献求助10
4秒前
4秒前
5秒前
5秒前
wenwen完成签到,获得积分10
5秒前
上善若水发布了新的文献求助10
5秒前
LLL完成签到,获得积分10
6秒前
寒冷归尘发布了新的文献求助10
6秒前
玖生发布了新的文献求助10
6秒前
6秒前
7秒前
7秒前
7秒前
123zyuyu完成签到,获得积分10
8秒前
8秒前
Dave完成签到 ,获得积分0
8秒前
8秒前
可爱的函函应助嘿嘿采纳,获得10
8秒前
小茉莉发布了新的文献求助30
9秒前
zhuzhu完成签到,获得积分10
9秒前
9秒前
海海发布了新的文献求助30
9秒前
9秒前
wanci应助xiaofan采纳,获得10
9秒前
10秒前
10秒前
10秒前
Cc发布了新的文献求助10
10秒前
Orange应助美丽寒凝采纳,获得10
11秒前
11秒前
大头驴发布了新的文献求助10
11秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3974559
求助须知:如何正确求助?哪些是违规求助? 3518949
关于积分的说明 11196503
捐赠科研通 3255066
什么是DOI,文献DOI怎么找? 1797673
邀请新用户注册赠送积分活动 877076
科研通“疑难数据库(出版商)”最低求助积分说明 806130