Mechanosynthesis of the Metallodrug Bismuth Subsalicylate from Bi2O3 and Structure of Bismuth Salicylate without Auxiliary Organic Ligands

Angewandte Chemie International EditionVolume 50, Issue 34 p. 7858-7861 Communication Mechanosynthesis of the Metallodrug Bismuth Subsalicylate from Bi2O3 and Structure of Bismuth Salicylate without Auxiliary Organic Ligands† Vânia André, Vânia André Centro de Quimica Estrutural, Instituto Superior Técnico, Universidade Técnica de Lisboa (Portugal)Search for more papers by this authorAndrew Hardeman, Andrew Hardeman Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK)Search for more papers by this authorDr. Ivan Halasz, Dr. Ivan Halasz Department of Chemistry, Faculty of Science, University of Zagreb (Croatia)Search for more papers by this authorDr. Robin S. Stein, Dr. Robin S. Stein Bruker UK Ltd, Banner Lane, Coventry CV4 9GH (UK)Search for more papers by this authorDr. Graham J. Jackson, Dr. Graham J. Jackson Department of Chemistry, University of Cape Town (South Africa)Search for more papers by this authorDr. David G. Reid, Dr. David G. Reid Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK)Search for more papers by this authorDr. Melinda J. Duer, Dr. Melinda J. Duer Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK)Search for more papers by this authorDr. Caroline Curfs, Dr. Caroline Curfs ESRF ID31, Grenoble Cedex (France)Search for more papers by this authorProf. M. Teresa Duarte, Prof. M. Teresa Duarte Centro de Quimica Estrutural, Instituto Superior Técnico, Universidade Técnica de Lisboa (Portugal)Search for more papers by this authorDr. Tomislav Friščić, Corresponding Author Dr. Tomislav Friščić [email protected] Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK)Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK)Search for more papers by this author Vânia André, Vânia André Centro de Quimica Estrutural, Instituto Superior Técnico, Universidade Técnica de Lisboa (Portugal)Search for more papers by this authorAndrew Hardeman, Andrew Hardeman Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK)Search for more papers by this authorDr. Ivan Halasz, Dr. Ivan Halasz Department of Chemistry, Faculty of Science, University of Zagreb (Croatia)Search for more papers by this authorDr. Robin S. Stein, Dr. Robin S. Stein Bruker UK Ltd, Banner Lane, Coventry CV4 9GH (UK)Search for more papers by this authorDr. Graham J. Jackson, Dr. Graham J. Jackson Department of Chemistry, University of Cape Town (South Africa)Search for more papers by this authorDr. David G. Reid, Dr. David G. Reid Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK)Search for more papers by this authorDr. Melinda J. Duer, Dr. Melinda J. Duer Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK)Search for more papers by this authorDr. Caroline Curfs, Dr. Caroline Curfs ESRF ID31, Grenoble Cedex (France)Search for more papers by this authorProf. M. Teresa Duarte, Prof. M. Teresa Duarte Centro de Quimica Estrutural, Instituto Superior Técnico, Universidade Técnica de Lisboa (Portugal)Search for more papers by this authorDr. Tomislav Friščić, Corresponding Author Dr. Tomislav Friščić [email protected] Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK)Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK)Search for more papers by this author First published: 07 July 2011 https://doi.org/10.1002/anie.201103171Citations: 106 † Herchel Smith fund is acknowledged for funding and a research fellowship (T.F.) and the BBSRC for financial support (D.G.R.). G.J.J. acknowledges a SA/UK Science Networks grant from the British Council administered by the RSC. V.A. acknowledges Fundação para a Ciência e a Tecnologia for funding (SFRH/BD/40474/2007). Dr. J. E. Davies is acknowledged for single-crystal diffraction data. Prof. R. E. Dinnebier is acknowledged for support in structure determination from powder diffraction data and Andy Fitch, ESRF, for support in synchrotron data collection. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Graphical Abstract Ground out: Mechanochemical methods gave the pharmaceutical ingredient bismuth subsalicylate, as well as bismuth disalicylate and trisalicylate directly from bismuth oxide. Structure determination by powder X-ray diffraction gave the first structure of a bismuth salicylate without auxiliary organic ligands (see picture: Bi yellow, O red, C gray, two salicylate ion coordination modes are shown in purple and green). Citing Literature Supporting Information Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description anie_201103171_sm_miscellaneous_information.pdf2.4 MB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume50, Issue34August 16, 2011Pages 7858-7861 RelatedInformation