细胞生物学
肌动蛋白细胞骨架
细胞骨架
GTP酶
生物
肌动蛋白重塑
电池极性
肌动蛋白
细胞
遗传学
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1998-01-23
卷期号:279 (5350): 509-514
被引量:5988
标识
DOI:10.1126/science.279.5350.509
摘要
The actin cytoskeleton mediates a variety of essential biological functions in all eukaryotic cells. In addition to providing a structural framework around which cell shape and polarity are defined, its dynamic properties provide the driving force for cells to move and to divide. Understanding the biochemical mechanisms that control the organization of actin is thus a major goal of contemporary cell biology, with implications for health and disease. Members of the Rho family of small guanosine triphosphatases have emerged as key regulators of the actin cytoskeleton, and furthermore, through their interaction with multiple target proteins, they ensure coordinated control of other cellular activities such as gene transcription and adhesion.
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