Industrially Viable Preparation of 2,2-Diisopropylpropionitrile, a Key Intermediate of Physiological Coolant WS-23 (2-Isopropyl-N,2,3-trimethylbutyramide)

Readily synthesized monosubstituted aliphatic acyclic carboxamides have a physiological cooling effect similar to that obtained with menthol. Among the monosubstituted aliphatic acyclic carboxamide...