静电纺丝
渗透(HVAC)
纳米纤维
制作
材料科学
纳米技术
组织工程
多孔性
细胞浸润
生物医学工程
复合材料
工程类
聚合物
炎症
病理
内科学
医学
替代医学
作者
Shian Zhong,Yanzhong Zhang,Chwee Teck Lim
出处
期刊:Tissue Engineering Part B-reviews
[Mary Ann Liebert]
日期:2012-04-01
卷期号:18 (2): 77-87
被引量:190
标识
DOI:10.1089/ten.teb.2011.0390
摘要
In the past decade, considerable effort has been made to construct biomimetic scaffolds from electrospun nanofibers for engineering different tissues. However, one of the major concerns with electrospun nanofibrous scaffolds is that the densely arranged architecture of fibers and small pores or voids between fibers hinder efficient cellular infiltration or prevent three dimensional (3D) cellular integration with host tissue in vivo after implantation. To overcome this problem, many concepts or strategies applicable during the electrospinning or post-electrospinning procedures have been proposed to enlarge pore size of electrospun scaffolds. This article addresses the issues of pore geometry and cellular infiltration of electrospun scaffolds, and first reviews the fabrication solutions/approaches applied to achieve larger micropores in electrospun mats. The evidence and potential for fostering cellular infiltration using these improved porous scaffolds are then discussed. Finally, it is hoped that this will enable us to better exploit viable technologies or develop new ones for constructing ideal nanofibrous architecture for fulfilling specific tissue engineering needs.
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