医学
质子抑制剂泵
中止
不利影响
泮托拉唑
非甾体
兰索拉唑
幽门螺杆菌
重症监护医学
胃肠病学
消化性溃疡
食管炎
内科学
药理学
奥美拉唑
疾病
回流
作者
Saman Chubineh,John Birk
标识
DOI:10.1097/smj.0b013e31826efbea
摘要
Proton pump inhibitors (PPIs) are one of the most commonly prescribed classes of medications in the United States. By inhibiting gastric H/K adenosine triphosphatase via covalent binding to the cysteine residues of the proton pump, they provide the most potent acid suppression available. Long-term PPI use accounts for the majority of total PPI use. Absolute indications include peptic ulcer disease, chronic nonsteroidal anti-inflammatory drugs use, treatment of Helicobacter pylori, and erosive esophagitis. Although PPIs are generally considered safe, numerous adverse effects, particularly associated with long-term use have been reported. Many patients receiving chronic PPI therapy do not have clear indications for their use, prompting consideration for reduction or discontinuation of their use. This article reviews the indications for PPI use, the adverse effects/risks involved with their use, and conditions in which their use is controversial.
科研通智能强力驱动
Strongly Powered by AbleSci AI