PI3K/AKT/mTOR通路
蛋白激酶B
P110α
生物
癌症研究
磷酸肌醇3激酶
癌症
细胞生物学
信号转导
遗传学
作者
Asif Khurshid Qazi,Aashiq Hussain,Abid Hamid,Yasrib Qurishi,Rabiya Majeed,Mudassier Ahmad,Rauf Ahmad Najar,Javeed Ahmad Bhat,Shashank Singh,Mohammad Afzal Zargar,Shakir Ali,Ajit Kumar Saxena
出处
期刊:Anti-cancer Agents in Medicinal Chemistry
[Bentham Science]
日期:2013-12-31
卷期号:13 (10): 1552-1564
被引量:24
标识
DOI:10.2174/1871520613666131125123241
摘要
Cancer is a diverse class of diseases which differ widely in their cause and biology. The aberrant behavior of cancer reflects up regulation of certain oncogenic signaling pathways that promote proliferation, inhibit apoptosis, and enable the cancer to spread and evoke angiogenesis. Phosphoinositide-3-kinase(PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway controls various biological processes that are important for normal functioning of the cell via cell cycle progression, survival, migration, transcription, translation and metabolism. However, PI3K signaling pathway is dysregulated almost in all cancers which is due to the amplification and genetic mutation of PI3K gene, encoding catalytic and regulatory subunit of PI3K isoforms. The current review focuses on the structural features of various PI3K isoforms including Akt and mTOR and their inhibition using specific small molecule inhibitors in an attempt to achieve an attractive target for cancer prevention and chemotherapy.
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