佐剂
体内
再繁殖
细胞
药理学
医学
药品
干细胞
辅助治疗
细胞疗法
造血干细胞
造血
化学
药物输送
免疫学
癌症研究
癌症
生物
材料科学
内科学
细胞生物学
纳米技术
生物化学
生物技术
作者
Matthias T. Stephan,James J. Moon,Soong Ho Um,Anna Bershteyn,Darrell J. Irvine
出处
期刊:Nature Medicine
[Springer Nature]
日期:2010-08-15
卷期号:16 (9): 1035-1041
被引量:646
摘要
A major limitation of cell therapies is the rapid decline in viability and function of the transplanted cells. Here we describe a strategy to enhance cell therapy via the conjugation of adjuvant drug-loaded nanoparticles to the surfaces of therapeutic cells. With this method of providing sustained pseudoautocrine stimulation to donor cells, we elicited marked enhancements in tumor elimination in a model of adoptive T cell therapy for cancer. We also increased the in vivo repopulation rate of hematopoietic stem cell grafts with very low doses of adjuvant drugs that were ineffective when given systemically. This approach is a simple and generalizable strategy to augment cytoreagents while minimizing the systemic side effects of adjuvant drugs. In addition, these results suggest therapeutic cells are promising vectors for actively targeted drug delivery.
科研通智能强力驱动
Strongly Powered by AbleSci AI