A Comparison of Whole-Genome Shotgun-Derived Mouse Chromosome 16 and the Human Genome

基因组同步生物人类基因组遗传学基因基因组计划霰弹枪测序基因密度染色体基因组进化同源染色体

作者

Richard J. Mural,Mark D. Adams,Eugene W. Myers,Hamilton O. Smith,George L. Gabor Miklos,Ron Wides,Aaron L. Halpern,Peter W. Li,Granger Sutton,Joe Nadeau,Steven L. Salzberg,Robert A. Holt,Chinnappa D. Kodira,Fu Lu,Lin Chen,Zuoming Deng,Carlos Evangelista,Weiniu Gan,Thomas J. Heiman,Jiayin Li,Zhen‐Ya Li,Gennady V. Merkulov,Natalia V. Milshina,Ashwinikumar K Naik,Rong Qi,Bixiong Chris Shue,Aihui Wang,Jian Wang,Xin Wang,Xianghe Yan,Jane J. Ye,Shibu Yooseph,Qi Zhao,Liansheng Zheng,Shiaoping C. Zhu,Kendra Biddick,Randall Bolanos,Arthur L. Delcher,Ian Dew,Daniel Fasulo,Michael J. Flanigan,Daniel H. Huson,Saul Kravitz,Jason R. Miller,Clark Mobarry,Knut Reinert,Karin Remington,Qing Zhang,Xiangqun H. Zheng,Deborah Nusskern,Zhongwu Lai,Yiding Lei,Wenyan Zhong,Alison Yao,Peng Guan,Rui‐Ru Ji,Zhiping Gu,Zhenyuan Wang,Fei Zhong,Chunlin Xiao,Chia-Chien Chiang,Mark Yandell,Jennifer Wortman,Peter G. Amanatides,Suzanne L Hladun,Eric C Pratts,Jeffery E Johnson,Kristina Dodson,Kerry J. Woodford,Cheryl Evans,Barry Gropman,Douglas B. Rusch,Eli Venter,Mei Wang,Thomas J. Smith,Jarrett Houck,Donald E Tompkins,Charles A. Haynes,Debbie Jacob,Soo H Chin,David R. Allen,Carl Dahlke,Robert D. Sanders,Kelvin Li,Xiangjun Liu,Alexander Levitsky,William H. Majoros,Quan Chen,Ashley C Xia,John Lopez,Michael Donnelly,Matthew Newman,Anna Glodek,Cheryl Kraft,Marc Nodell,Feroze Ali,Hui-Jin An,Danita Baldwin-Pitts,Karen Beeson,Shuang Cai,M. Katherine Carnes,Amy Carver,Parris M Caulk,Angela Center,Yen‐Hui Chen,Ming-Lai Cheng,My D Coyne,Michelle Crowder,Steven Danaher,Lionel B. Davenport,Raymond Desilets,Susanne Dietz,Lisa Doup,Patrick Dullaghan,Steven Ferriera,Carl Fosler,Harold C Gire,Andres Gluecksmann,Jeannine D. Gocayne,Jonathan Gray,Brit J. Hart,Jason Haynes,Jeffery Hoover,Tim Howland,Chinyere Ibegwam,Mena Jalali,David G. Johns,Leslie Kline,Sandro Natal Daniel,Steven MacCawley,Anand Magoon,Felecia Mann,David May,Tina C McIntosh,Somil C. Mehta,Linda Moy,Mee Moy,Brian J. Murphy,Sean D. Murphy,Keith A Nelson,Zubeda Nuri,Kimberly A. Parker,Alexandre C Prudhomme,Vinita Puri,Hina Qureshi,John C Raley,Matthew Reardon,Megan A. Regier,Yu-Hui C Rogers,Deanna L Romblad,Jakob Schutz,John L Scott,Rodney J. Scott,Cynthia Sitter,Michella Smallwood,Arlan C Sprague,Erin Stewart,Renee Strong,Ellen Suh,Karena Sylvester,Reginald Thomas,Ni Ni Tint,Christopher Tsonis,Gary Wang,George Wang,Monica S Williams,S. M. Williams,Sandra M Windsor,Keriellen Wolfe,Mitchell M Wu,Jayshree Zaveri,Kabir Chaturvedi,Andrei Gabrielian,Zhaoxi Ke,Jing‐Tao Sun,G. Subramanian,J. Craig Venter

出处

期刊：Science [American Association for the Advancement of Science (AAAS)]
日期：2002-05-31 卷期号：296 (5573): 1661-1671 被引量：356

链接

nih.govdoi.org

标识

DOI：10.1126/science.1069193

摘要

The high degree of similarity between the mouse and human genomes is demonstrated through analysis of the sequence of mouse chromosome 16 (Mmu 16), which was obtained as part of a whole-genome shotgun assembly of the mouse genome. The mouse genome is about 10% smaller than the human genome, owing to a lower repetitive DNA content. Comparison of the structure and protein-coding potential of Mmu 16 with that of the homologous segments of the human genome identifies regions of conserved synteny with human chromosomes (Hsa) 3, 8, 12, 16, 21, and 22. Gene content and order are highly conserved between Mmu 16 and the syntenic blocks of the human genome. Of the 731 predicted genes on Mmu 16, 509 align with orthologs on the corresponding portions of the human genome, 44 are likely paralogous to these genes, and 164 genes have homologs elsewhere in the human genome; there are 14 genes for which we could find no human counterpart.

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A Comparison of Whole-Genome Shotgun-Derived Mouse Chromosome 16 and the Human Genome

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