EXPERIMENTAL PARTIAL UNILATERAL URETER OBSTRUCTION. I. PRESSURE FLOW RELATIONSHIP IN A RAT MODEL WITH MILD AND SEVERE ACUTE URETER OBSTRUCTION

No AccessJournal of UrologyInvestigative Urology1 Oct 1998EXPERIMENTAL PARTIAL UNILATERAL URETER OBSTRUCTION. I. PRESSURE FLOW RELATIONSHIP IN A RAT MODEL WITH MILD AND SEVERE ACUTE URETER OBSTRUCTION JIAN GUO WEN, YUE CHEN, JORGEN FROKIAER, TROELS MUNCH JORGENSEN, and JENS CHRISTIAN DJURHUUS JIAN GUO WENJIAN GUO WEN Requests for reprints: Inst. Exp. Clinical Research, Skejby Hospital, Aarhus University, DK-8200 Aarhus N, Denmark. More articles by this author , YUE CHENYUE CHEN More articles by this author , JORGEN FROKIAERJORGEN FROKIAER More articles by this author , TROELS MUNCH JORGENSENTROELS MUNCH JORGENSEN More articles by this author , and JENS CHRISTIAN DJURHUUSJENS CHRISTIAN DJURHUUS More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)62614-4AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: To create an animal model with mild and severe partial unilateral ureter obstruction in young rats using a modified Ulm and Miller technique and to characterize the model by acute renal pelvic pressure measurements. Material and Methods: During anesthesia the upper fourth (n = 15) or the upper two-thirds of the left ureter (n = 15) was embedded into the psoas muscle causing either a mild or severe partial obstruction. Sham-operated control rats were prepared in paralllel (n = 20). The baseline pelvic pressure, the perfusion pelvic pressure (perfusion rates: 0.2 to 1.0 ml. per minute) and peristaltic waves were recorded after a resting period. Results: Mean baseline pelvic pressure and perfusion pelvic pressure were significantly higher in obstructed kidneys than in non-obstructed kidneys, and significantly higher in severely obstructed kidneys than in mildly obstructed kidneys (p <0.05). A fair linear relationship existed between the increase in pelvic pressure and the increase in perfusion rates in all groups. In the severely obstructed kidneys, baseline pelvic pressure was 16.9 ± 2.3 cm. H2 O and the perfusion pelvic pressure increased significantly from 41.7 ± 3.3 cm. H2 O to 68.6 ± 6.3 cm. H2 O. The pelvic peristaltic amplitude increased significantly following the increase in perfusion rate and there was a significant difference in the amplitude between severely obstructed and non-obstructed kidneys when the perfusion rate exceeded 0.4 ml. per minute (p <0.05). Conclusion: Embedding either the upper fourth or the upper two-thirds of the ureter into the psoas muscle produced a mild or a severe partial obstruction. In the latter model a significant increase in pelvic pressure and amplitude was observed, indicating the existence of severe obstruction. References 1 : Morphological correlates of renal growth arrest in neonatal partial ureteral obstruction. Pediatr. Res.1987; 21: 338. Google Scholar 2 : Suspected pyelo-ureteral junction obstruction in the fetus: when to do what? II. Experimental viewpoints. Eur. Urol.1991; 19: 132. Google Scholar 3 : An operation to produce experimental reversible hydronephrosis in dogs. J. Urol.1962; 88: 337. 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Google Scholar From the Institute of Experimental Clinical Research, University of Aarhus and Department of Urology K, Skejby University Hospital, Aarhus, Denmark© 1998 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byWEN J, CHEN Y, RINGGAARD S, FRØKIÆR J, JØRGENSEN T, STØDKILDE-JØRGENSEN H and DJURHUUS J (2018) EVALUATION OF RENAL FUNCTION IN NORMAL AND HYDRONEPHROTIC KIDNEYS IN RATS USING GADOLINIUM DIETHYLENETETRAMINE-PENTAACETIC ACID ENHANCED DYNAMIC MAGNETIC RESONANCE IMAGINGJournal of Urology, VOL. 163, NO. 4, (1264-1270), Online publication date: 1-Apr-2000.WEN J, RINGGAARD S, FROKIAER J, JORGENSEN T, STODKILDE-JORGENSEN H and DJURHUUS J (2018) CONTRALATERAL COMPENSATORY KIDNEY GROWTH IN RATS WITH PARTIAL UNILATERAL URETERAL OBSTRUCTION MONITORED BY MAGNETIC RESONANCE IMAGINGJournal of Urology, VOL. 162, NO. 3 Part 2, (1084-1089), Online publication date: 1-Sep-1999. Volume 160Issue 4October 1998Page: 1567-1571 Advertisement Copyright & Permissions© 1998 by American Urological Association, Inc.MetricsAuthor Information JIAN GUO WEN Requests for reprints: Inst. Exp. Clinical Research, Skejby Hospital, Aarhus University, DK-8200 Aarhus N, Denmark. More articles by this author YUE CHEN More articles by this author JORGEN FROKIAER More articles by this author TROELS MUNCH JORGENSEN More articles by this author JENS CHRISTIAN DJURHUUS More articles by this author Expand All Advertisement PDF downloadLoading ...