生物
细胞生物学
遗忘
调节器
翻译(生物学)
免疫沉淀
肌动蛋白
神经科学
信使核糖核酸
遗传学
基因
语言学
哲学
作者
N.O. Hadziselimovic,Vanja Vukojević,Péter Fábián,Annette Milnik,Matthias Fastenrath,Bánk G. Fenyves,Petra Hieber,Philippe Demougin,Christian Vogler,Dominique J.‐F. de Quervain,Andreas Papassotiropoulos,Attila Steták
出处
期刊:Cell
[Elsevier]
日期:2014-03-01
卷期号:156 (6): 1153-1166
被引量:89
标识
DOI:10.1016/j.cell.2014.01.054
摘要
Summary
A plastic nervous system requires the ability not only to acquire and store but also to forget. Here, we report that musashi (msi-1) is necessary for time-dependent memory loss in C. elegans. Tissue-specific rescue demonstrates that MSI-1 function is necessary in the AVA interneuron. Using RNA-binding protein immunoprecipitation (IP), we found that MSI-1 binds to mRNAs of three subunits of the Arp2/3 actin branching regulator complex in vivo and downregulates ARX-1, ARX-2, and ARX-3 translation upon associative learning. The role of msi-1 in forgetting is also reflected by the persistence of learning-induced GLR-1 synaptic size increase in msi-1 mutants. We demonstrate that memory length is regulated cooperatively through the activation of adducin (add-1) and by the inhibitory effect of msi-1. Thus, a GLR-1/MSI-1/Arp2/3 pathway induces forgetting and represents a novel mechanism of memory decay by linking translational control to the structure of the actin cytoskeleton in neurons.
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