二甲双胍
癌症
癌细胞
糖尿病
医学
药品
癌症研究
生物信息学
计算生物学
药理学
生物
内科学
内分泌学
作者
Osama A. Arshad,Priyadharshini S. Venkatasubramani,Aniruddha Datta,Jijayanagaram Venkatraj
出处
期刊:IEEE Journal of Biomedical and Health Informatics
[Institute of Electrical and Electronics Engineers]
日期:2016-01-01
卷期号:20 (1): 399-407
被引量:8
标识
DOI:10.1109/jbhi.2014.2368391
摘要
The uncontrolled cell proliferation that is characteristically associated with cancer is usually accompanied by alterations in the genome and cell metabolism. Indeed, the phenomenon of cancer cells metabolizing glucose using a less efficient anaerobic process even in the presence of normal oxygen levels, termed the Warburg effect, is currently considered to be one of the hallmarks of cancer. Diabetes, much like cancer, is defined by significant metabolic changes. Recent epidemiological studies have shown that diabetes patients treated with the antidiabetic drug Metformin have significantly lowered risk of cancer as compared to patients treated with other antidiabetic drugs. We utilize a Boolean logic model of the pathways commonly mutated in cancer to not only investigate the efficacy of Metformin for cancer therapeutic purposes but also demonstrate how Metformin in concert with other cancer drugs could provide better and less toxic clinical outcomes as compared to using cancer drugs alone.
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