海马体
海马结构
萧条(经济学)
大脑大小
心理学
扁桃形结构
颞叶
磁共振成像
内科学
医学
神经科学
放射科
癫痫
宏观经济学
经济
作者
J. Douglas Bremner,Murli Narayan,Eric Anderson,Lawrence H. Staib,Helen Miller,Dennis S. Charney
标识
DOI:10.1176/ajp.157.1.115
摘要
Elevated levels of glucocorticoids in depression have been hypothesized to be associated with damage to the hippocampus, a brain area involved in learning and memory. The purpose of this study was to measure hippocampal volume in patients with depression.Magnetic resonance imaging was used to measure the volume of the hippocampus in 16 patients with major depression in remission and 16 case-matched nondepressed comparison subjects.Patients with depression had a statistically significant 19% smaller left hippocampal volume than comparison subjects, without smaller volumes of comparison regions (amygdala, caudate, frontal lobe, and temporal lobe) or whole brain volume. The findings were significant after brain size, alcohol exposure, age, and education were controlled for.These findings are consistent with smaller left hippocampal volume in depression.
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