作者
Weiqi Zhang,Jingyi Li,Keiichiro Suzuki,Jing Qu,Ping Wang,Junzhi Zhou,Xiaomeng Liu,Ruotong Ren,Xiuling Xu,Alejandro Ocampo,Tingting Yuan,Jiping Yang,Ying Li,Liang Shi,Dee Guan,Huize Pan,Shunlei Duan,Zhichao Ding,Mo Li,Fei Yi,Ruijun Bai,Ya‐Yu Wang,Chang Chen,Fuquan Yang,Xiaoyu Li,Zimei Wang,Emi Aizawa,April Goebl,Rupa Devi Soligalla,Pradeep Reddy,Concepción Rodrı́guez Esteban,Fuchou Tang,Guang‐Hui Liu,Juan Carlos Izpisúa Belmonte
摘要
Heterochromatin in aging stem cells Analysis of human aging syndromes, such as Werner syndrome (WS), may lead to greater understanding of both premature and normal aging. Zhang et al. generated isogenic WS-specific human embryonic stem cell lines (see the Perspective by Brunauer and Kennedy). WS-mesenchymal stem cells displayed features characteristic of premature aging, including heterochromatin disorganization. WRN protein thus functions in the maintenance of heterochromatin, and heterochromatin alterations may represent a driving force of human aging. Science , this issue p. 1160 ; see also p. 1093