还原胺化
化学
小学(天文学)
醛
胺气处理
胺化
保护组
氢化物
有机化学
一锅法合成
氨
组合化学
功能群
催化作用
金属
烷基
天文
聚合物
物理
作者
Emma M. Dangerfield,Catherine H. Plunkett,Anna L. Win‐Mason,Bridget L. Stocker,Mattie S. M. Timmer
摘要
New methodology for the protecting-group-free synthesis of primary amines is presented. By optimizing the metal hydride/ammonia mediated reductive amination of aldehydes and hemiacetals, primary amines were selectively prepared with no or minimal formation of the usual secondary and tertiary amine byproduct. The methodology was performed on a range of functionalized aldehyde substrates, including in situ formed aldehydes from a Vasella reaction. These reductive amination conditions provide a valuable synthetic tool for the selective production of primary amines in fewer steps, in good yields, and without the use of protecting groups.
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