The Combined Effect of Cortisone and Partial Protein Depletion on Wound Healing

MANY investigators have reported retardation of wound healing by cortisone or ACTH.1 2 3 4 5 6 7 They have noted the depressant action on many phases of healing, including vascular growth, fibro-plasia and the deposition of normally staining extracellular material. Relative absence of the inflammatory elements but only slight slowing of epithelization has also been observed. These observations were made on different laboratory animals, using different methods of wounding.There have been, however, several clinical reports on patients with burns and surgical wounds that healed normally in the presence of ACTH or cortisone administration.8 9 10 11 12 13 Some have attributed this difference to inadequate or too infrequent administration . . .