间质细胞
纳米医学
癌症
肿瘤微环境
基质
癌症研究
医学
疾病
肿瘤细胞
生物信息学
内科学
纳米技术
生物
纳米颗粒
材料科学
免疫组织化学
作者
Aniruddha Roy,Shyh‐Dar Li
摘要
Treatment of cancer has come a long way from the initial ‘radical surgeries’ to the multimodality treatments. For the major part of the last century, cancer was considered as a monocellular disorder, and treatment strategies were designed according to that hypothesis. However, the mortality rate from cancer continued to be high and a comprehensive treatment remained elusive. Recent progress in research has demonstrated that tumors are a complex network of neoplastic and non‐neoplastic cells. The non‐neoplastic cells, which are collectively called stroma, assist in tumor survival and progression. It has been shown that disrupting the tumor‐stromal balance leads to significant effects on the tumor survival, and effective treatment can be achieved by targeting one or more of the stromal components. In this review, we summarize the roles of various stromal components in promoting tumor progression, and discuss innovative nanoparticle‐mediated drug targeting strategies for stromal depletion and the subsequent effects on the tumors. Perspectives and the future directions are also provided. WIREs Nanomed Nanobiotechnol 2016, 8:891–908. doi: 10.1002/wnan.1406 This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease
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