尿酸
黄嘌呤
次黄嘌呤
内分泌学
排泄
内科学
医学
别嘌呤醇
胰高血糖素
嘌呤
泌尿系统
肾功能
高尿酸血症
肌酐
生物化学
化学
激素
酶
作者
Tetsuya Yamamoto,Y Moriwaki,S. Takahashi,Zenta Tsutsumi,Keisai Hiroishi,Jun-ichi Yamakita,Tomoko Nakano,Kazuya Higashino
出处
期刊:PubMed
日期:1997-04-01
卷期号:24 (4): 708-13
被引量:13
摘要
To investigate whether glucagon increases the urinary excretion of oxypurinol and purine bases.We administered 1 mg glucagon intravenously to 5 healthy subjects taking 300 mg allopurinol orally, and determined plasma concentrations and urinary excretion of oxypurinol and purine bases.Glucagon increased the urinary excretion and fractional clearances of uric acid, xanthine, and oxypurinol, together with an increase in creatinine clearance, while it decreased plasma concentrations of xanthine and hypoxanthine.Glucagon-induced increases in urinary excretion of uric acid, xanthine, and oxypurinol were attributable to increases in the fractional clearances of uric acid, xanthine, and oxypurinol in addition to an increase in glomerular filtration rate. It is suggested that glucagon affects the renal common transport pathway of uric acid, xanthine, and oxypurinol by stimulating the release of a liver derived renal vasodilator.
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