Effect of creatine monohydrate supplementation on learning, memory and neuromuscular coordination in female albino mice

莫里斯水上航行任务 断奶 肌酸 一水肌酸 开阔地 医学 啮齿动物 体重 运动协调 内科学 内分泌学 安慰剂 生理学 动物科学 生物 病理 海马体 生态学 替代医学 精神科
作者
Razia Allahyar,Atif Akbar,Furhan Iqbal
出处
期刊:Acta Neuropsychiatrica [Cambridge University Press]
卷期号:29 (1): 27-34 被引量:11
标识
DOI:10.1017/neu.2016.28
摘要

Research findings made over the last few years have highlighted the important role of creatine (Cr) in health and disease. However, limited information is available regarding the effect of Cr supplementation on cognation. Present study was designed to determine the effect of variable doses of Cr (1% and 3%) on selected parameters of female albino mice behaviour.Following weaning, on 20th postnatal day, female albino mice were divided into three groups on the basis of dietary supplementation. Control group were was fed with normal rodent diet, whereas treated groups received diet supplemented with 1% and 3% Creatine monohydrate (Ssniff, Germany) for 10 weeks. Morris water maze (MWM), Rota rod and open field (OF) tests were carried out at the end of diet supplementation for neurofunctional assessment in all the groups.Data analysis showed that Cr supplementation did not affect the muscular activity and during rota rod test as well as locomotor and exploratory behaviour during OF test. Results of MWM probe trial indicated that mice supplemented with 3% Cr had significantly more entries in platform area than other two treatments (p=0.03) indicating improved spatial memory. Body weight remained unaffected (p>0.05) when compared between three experimental treatments.Female mice supplemented with 3% Cr showed improved spatial memory than mice fed on 1% Cr-supplemented diet and mice on normal rodent diet.
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