The ACE (Albumin, CRP, and Endoscopy) Index in Acute Colitis: Simplify to a Better Prognostic Prediction

To the Editors, We read with great interest your article entitled “The ACE (Albumin, CRP and Endoscopy) Index in Acute Colitis: A Simple Clinical Index on Admission that Predicts Outcome in Patients With Acute Ulcerative Colitis.” 1 In fact, we believe it is an issue of great clinical relevance in the management of patients with acute ulcerative colitis (AUC). It is crucial to identify patients with a predicable steroid nonresponse (SNR) in order to anticipate the need for rescue therapies and exclude contraindications. The available scores, due to their complexity, are often difficult to use in clinical practice. Moreover, some of these scores included variables only available days after patient admission, not allowing an attempt at prediction of clinical course. This issue has already been a topic of investigation by our work group who analyzed the accuracy of the different scores available to evaluate the severity of AUC. We performed...