Emu Oil Attenuates Disease Severity and Results in Fewer Large Colonic Tumors in a Mouse Model of Colitis-Associated Colorectal Cancer

偶氮甲烷 医学 结肠炎 胃肠病学 内科学 结直肠癌 溃疡性结肠炎 生理盐水 炎症性肠病 粘蛋白 癌症 疾病 病理
作者
Suzanne Mashtoub,Lauren C. Chartier,Debbie Trinder,Ian C. Lawrance,Gordon S. Howarth
出处
期刊:Nutrition and Cancer [Routledge]
卷期号:74 (2): 715-723 被引量:5
标识
DOI:10.1080/01635581.2021.1909737
摘要

Ulcerative colitis patients have an increased risk of developing colorectal cancer (CRC). The aim of the current study was to determine whether Emu Oil (EO) could reduce the severity of colitis, thereby inhibiting colitis-associated CRC (CA-CRC) development. Female C57BL/6 mice (n = 8/group) were injected (i.p.) with saline or azoxymethane (AOM) (7.4 mg/kg). Mice underwent three dextran sulfate sodium (DSS)/water cycles. Mice were orally-administered either water (160 µL) or EO (80 µL or 160 µL) thrice weekly and euthanized after 12 weeks. AOM/DSS decreased bodyweight compared with normal controls (max. 20%; p < 0.05). In AOM/DSS mice, EO (160 µL) increased bodyweight compared with untreated and 80 µL EO-treated mice (max. 10%; p < 0.05). Both volumes of EO reduced disease activity index (DAI) scores on day 49, 56–63 (max. 40%; p < 0.05), compared with AOM/DSS controls. Histological damage was increased in the distal colon of AOM/DSS mice, and reduced by EO (160 µL; p < 0.05). Mucin-secreting goblet cells were increased by AOM/DSS compared to normal, with no effect observed following EO treatment (p > 0.05). Large tumor numbers were decreased in EO-treated mice (160 µL; 2 ± 0.6) compared with AOM/DSS controls (5 ± 0.7; p < 0.05). EO did not impact overall tumor number (p > 0.05). Other analyses remained unchanged across groups (p > 0.05). EO demonstrates promise as an adjunct to conventional treatment options for colitis management.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
不安的半梦完成签到,获得积分10
1秒前
小胡先森发布了新的文献求助10
1秒前
迷路以蓝完成签到,获得积分10
2秒前
FashionBoy应助小柠檬采纳,获得10
2秒前
2秒前
2秒前
慕青应助顾难摧采纳,获得10
2秒前
holland完成签到 ,获得积分10
3秒前
小糊涂仙完成签到,获得积分10
3秒前
酷波er应助奋斗画板采纳,获得10
3秒前
zhaoty发布了新的文献求助10
4秒前
Zmy完成签到,获得积分10
4秒前
万能图书馆应助kgrvlm采纳,获得10
4秒前
亚米完成签到,获得积分10
4秒前
ZT发布了新的文献求助10
4秒前
4秒前
不得发布了新的文献求助10
6秒前
不安雁开完成签到,获得积分10
6秒前
求帮助完成签到,获得积分10
6秒前
cc发布了新的文献求助10
6秒前
皇甫妙竹完成签到,获得积分10
6秒前
6秒前
book卟完成签到 ,获得积分10
7秒前
sijia完成签到,获得积分10
7秒前
小胡先森完成签到,获得积分10
7秒前
8秒前
9秒前
松鼠发布了新的文献求助10
9秒前
9秒前
涛哥完成签到,获得积分10
9秒前
Lucas应助whuhustwit采纳,获得10
9秒前
10秒前
Linlin完成签到,获得积分10
10秒前
10秒前
CipherSage应助哇哈哈哈哈哈采纳,获得10
10秒前
11秒前
zhaoty完成签到,获得积分10
11秒前
11秒前
王晓蕾完成签到,获得积分10
11秒前
TheaGao完成签到 ,获得积分10
11秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3974643
求助须知:如何正确求助?哪些是违规求助? 3519094
关于积分的说明 11196979
捐赠科研通 3255182
什么是DOI,文献DOI怎么找? 1797700
邀请新用户注册赠送积分活动 877100
科研通“疑难数据库(出版商)”最低求助积分说明 806130