G蛋白偶联受体
化学
拟肽
受体
计算生物学
G蛋白
细胞生物学
结构生物学
小分子
生物化学
蛋白质-蛋白质相互作用
变构调节
视紫红质样受体
肽
配体(生物化学)
药物发现
作者
Ryan H. Gumpper,Bryan L. Roth
标识
DOI:10.1016/j.tips.2021.03.009
摘要
Technologies stabilizing the active state of G protein-coupled receptors (GPCRs) represent potential breakthroughs for interrogating G protein activation. Camelid nanobodies have been used as a 'one tool, one receptor' paradigm. However, the development of G protein peptidomimetics, as discussed in Mannes et al. represent the opportunity to develop generically activating probes for many GPCRs.
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