赫拉
细胞毒性
细胞毒性T细胞
MTT法
癌细胞系
传统医学
松属
化学
体外
生物
癌细胞
植物
生物化学
癌症
医学
遗传学
作者
Annise Proboningrat,Amaq Fadholly,Sri Agus Sudjarwo,Fedik Abdul Rantam,Agung Budianto Achmad
标识
DOI:10.1051/bioconf/20213303001
摘要
Several efforts have been made to discover new anticancer agents based on natural ingredients. Meanwhile, previous studies have shown that different Pine genus species exhibit cytotoxic activity against various types of cancer cells. This plant is rich in phenolic compounds, especially procyanidins, flavonoids, and phenolic acids. Therefore, this study aims to investigate the in vitro cytotoxicity of Pinus merkusii needles extract on HeLa cancer cell lines. The cytotoxicity assessment was measured using MTT assay and expressed as IC 50 value. The results showed that the ethanolic extract poses a dose and time-dependent cytotoxic activity with an IC 50 value of 542.5 µg/ml at 48 hours of incubation. Based on this result, Pinus merkusii needles’ ethanolic extract has the potential of a novel candidate for an anticancer agent.
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