葡萄糖氧化酶
化学
癌细胞
纳米点
谷胱甘肽
癌症治疗
体外
饥饿
肿瘤细胞
癌症
生物化学
生物物理学
癌症研究
生物
酶
医学
内科学
内分泌学
物理化学
作者
Jie Wang,Lijia Yao,Enlai Hu,Yuanjing Cui,Deren Yang,Guodong Qian
标识
DOI:10.1016/j.jssc.2021.122102
摘要
Recently, chemodynamic and cell starvation therapy have been regarded as an impressive method for the cancer treatment. Herein, a nanoplatform was developed by decorating MnO2 nanodots on glucose oxidase (GOx) encapsulated in ZIF-8, in which MnO2 nanodots can firstly consume overexpressed glutathione (GSH) to avoid the side reaction between GSH and ·OH. Then, the MnO2 will release Mn2+ to trigger the beginning of Fenton-like reaction for the formation of ·OH species by catalyzing H2O2, one of the oxidation products of d-glucose in tumor cells. Meanwhile, the GOx can degrade d-glucose, the essential nutrient for the tumor cells, to deliver H2O2, the precursor of ·OH species, which will cause starvation for cancer cells. Vitro experimental measurement further demonstrated the prominent performance of the MnO2 decorated [email protected] on killing cancer cells. We believe that the remarkable effect of chemodynamic and cancer starvation therapy in this work can provide a new prospect for cancer therapy.
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