造血
生物
祖细胞
干细胞
免疫学
血细胞
集合(抽象数据类型)
细胞分裂
计算生物学
细胞
细胞生物学
计算机科学
遗传学
程序设计语言
作者
Jason Cosgrove,Lucie S.P. Hustin,Rob J. de Boer,Leïla Perié
标识
DOI:10.1016/j.it.2021.10.006
摘要
Hematopoiesis is a dynamic process in which stem and progenitor cells give rise to the ~1013 blood and immune cells distributed throughout the human body. We argue that a quantitative description of hematopoiesis can help consolidate existing data, identify knowledge gaps, and generate new hypotheses. Here, we review known numbers in murine and, where possible, human hematopoiesis, and consolidate murine numbers into a set of reference values. We present estimates of cell numbers, division and differentiation rates, cell size, and macromolecular composition for each hematopoietic cell type. We also propose guidelines to improve the reporting of measurements and highlight areas in which quantitative data are lacking. Overall, we show how quantitative approaches can be used to understand key properties of hematopoiesis.
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