[Lingnan fire needling combined with 0.1% sodium hyaluronate eye drops in the treatment of xerophthalmia: a randomized controlled trial].

To observe the effect of Lingnan fire needling combined with artificial tears in the treatment of xerophthalmia.A total of 86 xerophthalmia patients were equally and randomly divided into treatment group and control group. The patients of both groups were received treatment with 0.1% sodium hyaluronate eye drops in their eyes 3 times a day, one drop in each eye. In addition, the patients of treatment group also treated by Lingnan fire needling on bilateral Shaoze (SI1), Neichengqi and beside lacrimal puncta once a week. The treatment was conducted for 4 consecutive weeks. Before and after 4 weeks of treatment, the clinical efficacy, visual acuity, intraocular pressure, ocular symptom score, OSDI score, fluorescence staining （FL） score, schemer I, tear menisci height, tear film break-up time (BUT) and eye redness index were recorded and evaluated.After the treatment, self-comparison showed that the symptom score, OSDI score, FL score and eye redness index were significantly decreased (P<0.05), and BUT was notably increased in both groups (P<0.05) in comparison with their own pre-treatment. The tear menisci height in the treatment group was higher than that before the treatment (P<0.05). Comparison between the two groups showed that the symptom score, OSDI score and eye redness index were obviously lower in the treatment group than in the control group (P<0.05), whereas the BUT and tear menisci height were evidently higher (P<0.05). The total effective rate of the treatment group was 84.88% (73/86), better than 76.74% (66/86) of the control group (P<0.05).Lingnan fire needling combined with 0.1% sodium hyaluronate eye drops is more effective than simple sodium hyaluronate eye drops for xerophthalmia patients, with significant curative effect and no adverse reactions.目的：评价岭南火针联合人工泪液治疗干眼症的临床疗效。方法：将86例干眼症患者随机分为治疗组和对照组，每组43例。对照组双眼滴用0.1%玻璃酸钠滴眼液，双眼每次各1滴，每日3次，连续治疗4周。治疗组在对照组基础上给予岭南火针治疗，取双侧少泽、内承泣、泪小点旁，每周治疗1次，连续治疗4周。治疗前后评价临床疗效及视力、眼压、眼部症状评分、眼表疾病指数(OSDI)评分、眼表荧光染色（FL）评分、泪膜破裂时间(BUT)、泪液分泌量(Schimer Ⅰ)的变化，以及使用Keratograph 眼表综合分析仪评价治疗前后泪河高度、眼红指数的变化。结果：与本组治疗前比较，两组治疗后双眼眼部症状评分、OSDI评分、FL评分、眼红指数均降低(P<0.05)，BUT均升高(P<0.05)；治疗组泪河高度较治疗前升高(P<0.05)。治疗后与对照组比较，治疗组双眼眼部症状评分、OSDI评分、眼红指数均降低(P<0.05)，BUT、泪河高度均升高(P<0.05)。对照组有效率为76.74%(66/86)，治疗组有效率为84.88%(73/86)，治疗组临床疗效高于对照组(P<0.05)。结论：岭南火针联合0.1%玻璃酸钠滴眼液可有效治疗干眼症，在改善干眼症状评分、OSDI评分、BUT、泪河高度、眼红指数等方面优于单纯玻璃酸钠滴眼液。.