生物催化
化学
酪氨酸
生物化学
大肠杆菌
酶
氨基酸
基质(水族馆)
胞浆
高分子
立体化学
生物
反应机理
催化作用
基因
生态学
作者
Zhongqiang Wang,Hayden Matthews,Guozhong Deng,Xiao‐Jian Zhou,Yongzheng Chen
摘要
The non-proteinogenic amino acids m-fluorotyrosine and 2,4-dihydroxyphenylalanine demonstrated a respective 6- and 12-fold greater binding affinity to the purified tyrosyl-tRNA synthetase from Escherichia coli than that from human cytosol. The differential binding was identified by probing the substrate selectivity of the two enzymes with structural analogues of tyrosine using a thermodynamic technique.
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