Confined structure regulations of molybdenum oxides for efficient tumor photothermal therapy

光热治疗 纳米反应器 材料科学 表面等离子共振 光热效应 纳米颗粒 纳米技术 介孔二氧化硅 氧化物 等离子体子 介孔材料 化学工程 化学 光电子学 催化作用 有机化学 冶金 工程类
作者
Limei Qin,Dechao Niu,Xing Qin,Qiqi Sun,Zicong Wen,Qili Yu,Yongsheng Li,Jianlin Shi
出处
期刊:Science China. Materials [Springer Science+Business Media]
卷期号:64 (12): 3087-3100 被引量:9
标识
DOI:10.1007/s40843-021-1692-1
摘要

Molybdenum oxide nanoparticles (NPs) with tunable plasmonic resonance in the near-infrared region display superior semiconducting features and photothermal properties, which are highly related to the crystalline and defective structures such as oxygen deficiencies. However, fundamental understanding on the structure-function relationship between crystalline/defective structures and photothermal properties is still unclear. To address this, herein, we have developed an “in-situ confined oxidation-reduction” strategy to regulate the defect features of molybdenum oxide NPs in the dual-mesoporous silica nanoreactor. Especially, the effects of crystalline structure/oxygen defects of molybdenum oxides on the photothermal performances were investigated by facilely tuning the amount of molybdenum resource and the reduction temperature. As a photothermal nanoagent, the optimal defective molybdenum oxide NPs encapsulated in PEGylated porous silica nanoreactor (designated as MoO3−x@PPSNs) exhibit excellent biological stability and strong localized surface plasmon resonance effect in near-infrared absorption range with the highest photothermal conversion efficiency up to 78.7% under 808 nm laser irradiation. More importantly, the remarkable photothermal effects of MoO3−xPPSNs were comprehensively demonstrated both in vitro and in vivo. Consequently, we envision that the plasmonic MoO3−x NPs in a biocompatible porous silica nano-reactor could be used as an efficient photothermal therapy agent for photothermal ablation of tumors.
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