光热治疗
纳米反应器
材料科学
钼
表面等离子共振
光热效应
纳米颗粒
纳米技术
介孔二氧化硅
氧化物
等离子体子
介孔材料
化学工程
化学
光电子学
催化作用
有机化学
冶金
工程类
作者
Limei Qin,Dechao Niu,Xing Qin,Qiqi Sun,Zicong Wen,Qili Yu,Yongsheng Li,Jianlin Shi
标识
DOI:10.1007/s40843-021-1692-1
摘要
Molybdenum oxide nanoparticles (NPs) with tunable plasmonic resonance in the near-infrared region display superior semiconducting features and photothermal properties, which are highly related to the crystalline and defective structures such as oxygen deficiencies. However, fundamental understanding on the structure-function relationship between crystalline/defective structures and photothermal properties is still unclear. To address this, herein, we have developed an “in-situ confined oxidation-reduction” strategy to regulate the defect features of molybdenum oxide NPs in the dual-mesoporous silica nanoreactor. Especially, the effects of crystalline structure/oxygen defects of molybdenum oxides on the photothermal performances were investigated by facilely tuning the amount of molybdenum resource and the reduction temperature. As a photothermal nanoagent, the optimal defective molybdenum oxide NPs encapsulated in PEGylated porous silica nanoreactor (designated as MoO3−x@PPSNs) exhibit excellent biological stability and strong localized surface plasmon resonance effect in near-infrared absorption range with the highest photothermal conversion efficiency up to 78.7% under 808 nm laser irradiation. More importantly, the remarkable photothermal effects of MoO3−xPPSNs were comprehensively demonstrated both in vitro and in vivo. Consequently, we envision that the plasmonic MoO3−x NPs in a biocompatible porous silica nano-reactor could be used as an efficient photothermal therapy agent for photothermal ablation of tumors.
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