阿霉素
肿瘤微环境
癌细胞
生物相容性
化学
癌症研究
纳米颗粒
体内
材料科学
药理学
癌症
纳米医学
药物输送
医学
生物物理学
纳米技术
化疗
内科学
生物
肿瘤细胞
有机化学
生物技术
作者
Fang Cheng,Shenqiang Wang,Hua Zheng,Shaowei Yang,Li Zhou,Kangkai Liu,Qiuyu Zhang,Hepeng Zhang
标识
DOI:10.1016/j.colsurfb.2021.111878
摘要
CeO2 nanoenzyme possesses multiple enzyme-mimicking activities and excellent biocompatibility. However, its weak peroxidase (POD)-mimicking property in the tumor microenvironment (TME) hinders its further tumor therapy application. To enhance CeO2 nanoenzyme’s POD activity and overcome limitations of single therapeutic modality, a novel antitumor controlled drug release system (CCCs NPs) was designed using Cu doped cerium oxide nanoparticles (Cu-CeO2 NPs) loaded with clinical anti-cancer drug doxorubicin (DOX) as the core and the breast cancer cell membrane as the outer shell. Cu doping endowed CeO2 NPs’ with significantly enhanced POD-mimicking activity in the TME due to a remarkably higher Ce3+/Ce4+ ratio. The cancer cell membrane coating enabled our nanomedicine with homotypic targeting property. Combined with chemotherapeutic drug DOX, a selective and nearly complete tumor suppression was demonstrated in vitro and in vivo. Remarkably, under physiological condition, CCCs NPs worked as a radical scavenger to protect normal cells from oxidative stress caused by anti-cancer drug DOX and OH generated via Fenton-like reaction. Collectively, our CCCs NPs offered a therapeutic potential for effective breast cancer therapy while being free of side effects.
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