Neuro‐Receptor Mediated Synapse Device Based on Crumpled MXene Ti3C2Tx Nanosheets

Abstract Artificial synapse devices can simulate the neuro‐transmission in a completely electronic way, but the neuro‐biochemical responses are still a challenge for them. Here, a novel three‐terminal (3T) neuro‐receptor‐mediated (acetylcholine receptor (AChR) as a proof‐of‐concept) synapse device (NR‐S) based on the solution–MXene interface is presented. It is demonstrated that the synaptic plasticity behavior triggered by neuro‐transmitter (ACh) and the pathogenic autoantibody (AChR‐ab) induced neuronal damage that can be detected and recorded. The improved sensitivities, including the linear responses to ACh in an extremely wide range (1 a m to 1 µ m ) and ultra‐low (1 a m ) limit of detection, are obtained using crumpled MXene. Furthermore, the ability of the proposed NR‐S to determine the tiny neuronal injury caused by only 10 ng mL −1 AChR‐ab is conceptually proven. Collectively, the novel 3T NR‐S has good application prospects in the field of the neuromorphic chip for not only realizing the bionic simulation of the chemically modulated or injured neuro‐transmission but also offering an efficient experimental platform for neuro‐biochemistry studies.