神经科学
生物
视皮层
感觉系统
神经元回路
生物神经网络
连接蛋白
缝隙连接
细胞生物学
句号(音乐)
细胞内
艺术
美学
作者
Jérôme Ribot,Rachel Breton,Charles‐Félix Calvo,Julien Moulard,Pascal Ezan,Jonathan Zapata,Kevin Samama,Matthieu X. Moreau,Alexis‐Pierre Bemelmans,Valentin Sabatet,Florent Dingli,Damarys Loew,Chantal Milleret,Pierre Billuart,Glenn Dallérac,Nathalie Rouach
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2021-07-01
卷期号:373 (6550): 77-81
被引量:70
标识
DOI:10.1126/science.abf5273
摘要
Brain postnatal development is characterized by critical periods of experience-dependent remodeling of neuronal circuits. Failure to end these periods results in neurodevelopmental disorders. The cellular processes defining critical-period timing remain unclear. Here, we show that in the mouse visual cortex, astrocytes control critical-period closure. We uncover the underlying pathway, which involves astrocytic regulation of the extracellular matrix, allowing interneuron maturation. Unconventional astrocyte connexin signaling hinders expression of extracellular matrix-degrading enzyme matrix metalloproteinase 9 (MMP9) through RhoA-guanosine triphosphatase activation. Thus, astrocytes not only influence the activity of single synapses but also are key elements in the experience-dependent wiring of brain circuits.
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