Peculiarities of the morphofunctional state of skin, to a large extent, depend on the state of microcirculation. As the skin nutrition is provided by the microvessels, the question arises if the disturbances in microcirculation affect the parametres of the morphofunctional state of the skin. The main clinical investigations on microcirculation are represented in this review: the influences of systemic and local microcirculatory disturbances on the physiological parameters of skin, as well as the age changes of microcirculation and their influences on the dermatosis have been elucidated. The main questions on physiology and pathology of the skin microcirculation and methods of their study have been described.