表观遗传学
染色质
组蛋白
DNA甲基化
生物
神经发生的表观遗传调控
后生
癌症
癌症表观遗传学
基因表达调控
疾病
表观遗传学
癌症研究
基因表达
基因
遗传学
计算生物学
生物信息学
染色质重塑
医学
病理
作者
Jing Wen Zhang,Qian Xu,Guoliang Li
出处
期刊:PubMed
日期:2019-07-20
卷期号:41 (7): 567-581
标识
DOI:10.16288/j.yczz.19-077
摘要
Cancer is a complex disease caused by the malignant cellular proliferation and metastasis. Elucidating its pathogenic mechanism is one of the major challenges that we face currently. Epigenetic mechanisms are essential for maintaining specific patterns of gene expression and normal development and growth of living individuals. Disorders of epigenetic markers, such as histone modification, DNA/RNA methylation, and changes in the three-dimensional conformation of chromatin, can interfere with gene expression to some extent, and result in cancers. This review provides a brief overview of epigenetics, focusing on their association with the genesis of cancers, and we look forward to the application of epigenetics in cancer clinical diagnosis and treatment.
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