代谢物
细胞代谢
癌细胞
生物
新陈代谢
功能(生物学)
癌症
肿瘤微环境
细胞
细胞代谢
细胞生物学
癌症研究
代谢途径
生物化学
遗传学
作者
Ilaria Elia,Marcia C. Haigis
标识
DOI:10.1038/s42255-020-00317-z
摘要
Metabolic transformation is a hallmark of cancer and a critical target for cancer therapy. Cancer metabolism and behaviour are regulated by cell-intrinsic factors as well as metabolite availability in the tumour microenvironment (TME). This metabolic niche within the TME is shaped by four tiers of regulation: (1) intrinsic tumour cell metabolism, (2) interactions between cancer cells and non-cancerous cells, (3) tumour location and heterogeneity and (4) whole-body metabolic homeostasis. Here, we define these modes of metabolic regulation and review how distinct cell types contribute to the metabolite composition of the TME. Finally, we connect these insights to understand how each of these tiers offers unique therapeutic potential to modulate the metabolic profile and function of all cells inhabiting the TME.
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