关节炎
血管生成
化学
血管翳
p38丝裂原活化蛋白激酶
类风湿性关节炎
PI3K/AKT/mTOR通路
软骨
破骨细胞
药理学
蛋白激酶B
癌症研究
免疫学
信号转导
细胞生物学
医学
生物
受体
MAPK/ERK通路
生物化学
解剖
作者
Zhen-Zi Shang,Dan-Yang Qin,Qiang-Ming Li,Xue‐Qiang Zha,Li‐Hua Pan,Daiyin Peng,Jian‐Ping Luo
标识
DOI:10.1016/j.carbpol.2021.117657
摘要
The present study explored the beneficial effect of Dendrobium huoshanense stem polysaccharide (cDHPS) after oral administration on rheumatoid arthritis (RA) using type Ⅱ collagen-induced arthritis (CIA) mouse model. It was found that cDHPS effectively alleviated joint swelling, synovial hyperplasia, pannus formation, cartilage erosion and bone destruction in CIA mice. Concurrently, cDHPS remodeled the balance of Th17 and regulatory T cells, reduced the secretion of pro-inflammatory mediators related to fibroblast-like synoviocyte activation, angiogenesis, articular cartilage degradation and osteoclast differentiation, inhibited HIF-1α expression and promoted anti-inflammatory mediator release in the joint tissues and serum of CIA mice. Western blot of joint tissues showed that cDHPS significantly inhibited the phosphorylation of IκB, p65, JNK, p38, ERK1/2, AKT, PI3K, JAK1 and STAT3 in CIA mice. These results suggest that cDHPS possesses the potential of ameliorating RA and its anti-RA effect may be attributed to the inhibition of inflammatory signaling pathways.
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