自愈水凝胶
肿胀 的
亚胺
高分子化学
水溶液
动态力学分析
化学工程
化学
壳聚糖
抗菌活性
材料科学
核化学
聚合物
有机化学
细菌
催化作用
工程类
生物
遗传学
作者
Rui Yu,Louis Cornette de Saint-Cyr,Laurence Soussan,Mihail Barboiu,Suming Li
标识
DOI:10.1016/j.ijbiomac.2020.11.068
摘要
Imine dynamic hydrogels are synthesized via dual-imine bond crosslinking from O-carboxymethyl chitosan (CMCS) and a water soluble dynamer using a ‘green’ approach. Three dynamers are prepared through reaction of benzene-1,3,5-tricarbaldehyde and di-amino Jeffamine with molar mass of 500, 800 and 1900, respectively. Hydrogels, namely H500, H800 and H1900 are then obtained by mixing CMCS and dynamer aqueous solutions. FT-IR confirms the formation of hydrogels via imine bonding. H1900 presents larger pore size and higher storage modulus as compared to H500 and H800 due to the higher molar mass of Jeffamine linker. The hydrogels exhibit pH sensitive swelling behavior due to electrostatic attraction or repulsion in the pH range from 3 to 10. The highest swelling ratio is obtained at pH 8, reaching 7500% for H800. Self-healing of hydrogels is evidenced by rheological measurements with alternatively applied low and high strains, and by using a macroscopic approach with re-integration of injected filaments. Furthermore, the H1900 membrane exhibits outstanding antibacterial activity against an E. coli suspension at 108 CFU mL−1. Therefore, dynamic hydrogels synthesized from CMCS and Jeffamine present outstanding rheological, swelling, self-healing and antibacterial properties, and are most promising as healthcare material in wound dressing, drug delivery and tissue engineering.
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