纳米孔
生物传感器
膜
分析物
计算机科学
纳米技术
材料科学
化学
色谱法
生物化学
作者
Zhenyu Chu,Wei Zhang,Qiannan You,Xiaoyue Yao,Tao Liu,Gongping Liu,Guangru Zhang,Xiaoping Gu,Zhengliang Ma,Wanqin Jin
标识
DOI:10.1002/anie.202008241
摘要
Abstract Dynamic and on‐site analysis of serum from human blood is crucial, however, state‐of‐the‐art blood‐assay methods can only collect single or discrete data of physiological analytes; thus, the online reports of the dynamic fluctuation of key analytes remains a great challenge. Here, we propose a novel separation‐sensing membrane by constructing a heterogeneous‐nanostructured architecture, wherein a surface nanoporous layer continuously extracts serum, while the biosensing nanochannels underneath dynamically recognise biotargets, thereby achieving a continuous testing of vital clinical indices as blood is drawn. By precisely controlling the pore structure and nanoshape of biosensing crystals, this membrane achieved accurate and online glucose and lactate monitoring in patients with a variety of medical conditions within 1 min, which is one order of magnitude faster than state‐of‐the‐art techniques. Moreover, various kinds of bio‐recognisers can be introduced into this membrane to accurately detect glutamate, transaminase, and cancer biomarkers.
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